✍ Scribed by Raymond M. Doss; Michael A. Marques; Shane Foister; Peter B. Dervan
No coin nor oath required. For personal study only.
📜 SIMILAR VOLUMES
This review surveys the crystal structures between minor groove drugs and oligonucleotides, of which over thirty have now been determined. The various factors that are involved in the observed A/T sequence selectivity of these drugs are examined in structural terms. The roles of, in particular, hydr
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## Abstract Crescent‐shaped polyamides composed of aromatic amino acids, __i.e.__, 1‐methyl‐1__H__‐imidazole **Im**, 1‐methyl‐1__H__‐pyrrole **Py**, and 3‐hydroxy‐1__H__‐pyrrole **Hp**, bind in the minor groove of DNA as 2 : 1 and 1 : 1 ligand/DNA complexes. DNA‐Sequence specificity can be attribut