𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Production of (2S,3S)-2,3-dihydro-3-hydroxy-2-(4-methoxyphenyl)-1,5-benzothiazepin-4(5H)-one, a key intermediate for diltiazem synthesis, by Bakers' yeast-mediated reduction

✍ Scribed by Tadashi Kometani; Yukiko Sakai; Hiroaki Matsumae; Takeji Shibatani; Ryuichi Matsuno


Book ID
114294128
Publisher
Elsevier Science
Year
1997
Tongue
English
Weight
653 KB
Volume
84
Category
Article
ISSN
0922-338X

No coin nor oath required. For personal study only.


📜 SIMILAR VOLUMES


Absolute Conformation and Configuration
✍ Biserka Kojić-Prodić; ŽIva Ružić-Toroš; Vitomir Šunjić; Enio Decorte; Flavio Moi 📂 Article 📅 1984 🏛 John Wiley and Sons 🌐 German ⚖ 572 KB

## Abstract Resolution of racemic __cis__‐3‐(2‐aminophenylthio)‐2‐hydroxy‐3‐(4‐methoxyphenyl) propionic acid (**2**) __via__ the cinchonidine salt **3**, and brucine salt **4**, isolation of the calcium salts (+)‐ and (−)‐**5**, as well as their cyclization to enantiomeric 1,5‐benzothiazepines (+)‐