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Preparation of (2S,3S)-2,3-dihydro-3-hydroxy-2-(4-methoxyphenyl)-1,5-benzothiazepin-4(5H)-one by microbial conversion

✍ Scribed by Takuo Noshida; Ikuko Machida; Hiroaki Matsumae; Shinichi Yamada; Yasuhiko Ozaki; Takeji Shibatani

Book ID
113397780
Publisher
Elsevier Science
Year
1996
Tongue
English
Weight
534 KB
Volume
81
Category
Article
ISSN
0922-338X

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## Abstract Resolution of racemic __cis__‐3‐(2‐aminophenylthio)‐2‐hydroxy‐3‐(4‐methoxyphenyl) propionic acid (**2**) __via__ the cinchonidine salt **3**, and brucine salt **4**, isolation of the calcium salts (+)‐ and (−)‐**5**, as well as their cyclization to enantiomeric 1,5‐benzothiazepines (+)‐