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Enantiomer associations in the crystal structures of racemic and (2S,3S)-(+)-3-hydroxy-2-(4-methoxyphenyl)-2,3-dihydro-1,5-benzothiazepin-4(5H)-one

✍ Scribed by Katalin Marthi; Sine Larsen; Mária Ács; Elemér Fogassy


Publisher
Elsevier Science
Year
1996
Tongue
English
Weight
779 KB
Volume
374
Category
Article
ISSN
0022-2860

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Absolute Conformation and Configuration
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## Abstract Resolution of racemic __cis__‐3‐(2‐aminophenylthio)‐2‐hydroxy‐3‐(4‐methoxyphenyl) propionic acid (**2**) __via__ the cinchonidine salt **3**, and brucine salt **4**, isolation of the calcium salts (+)‐ and (−)‐**5**, as well as their cyclization to enantiomeric 1,5‐benzothiazepines (+)‐