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Microbial asymmetric reduction of (RS)-2-(4-methoxyphenyl)-1,5-benzothiazepin-3,4(2H,5H)-dione, the key intermediate in the synthesis of diltiazem hydrochloride

✍ Scribed by Hiroaki Matsumae; Hiroshi Douno; Shinichi Yamada; Takuo Nishida; Yasuhiko Ozaki; Takeji Shibatani; Tetsuya Tosa


Book ID
113397577
Publisher
Elsevier Science
Year
1995
Tongue
English
Weight
626 KB
Volume
79
Category
Article
ISSN
0922-338X

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The synthesis of 7-chloro-5-pentadeuteri
✍ Anthony G. Borel; Frank S. Abbott πŸ“‚ Article πŸ“… 1990 πŸ› John Wiley and Sons 🌐 French βš– 452 KB

## Abstract Pentadeuteriophenyl clobazam 5 was synthesized in essentially quantitative isotopic purity, and characterized by ^1^H‐NMR and mass spectroscopy. The title compound was found to be β‰₯98% pure by HPLC, and its retention time (t~R~ 6.17 min) was less than that of an authentic clobazam stand