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Product inhibition of benzo[a]pyrene metabolism in uninduced rat liver microsomes: Effect of diol epoxide formation

✍ Scribed by Gabriela M. Keller; Maro Christou; Lynn H. Pottenger; Neil M. Wilson; Colin R. Jefcoate

Book ID
113137002
Publisher
Elsevier Science
Year
1987
Tongue
English
Weight
976 KB
Volume
61
Category
Article
ISSN
0009-2797

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## Abstract Treatment of isolated rat liver nuclei with 7Ξ², 8α‐dihydroxy‐9Ξ±, 10α‐epoxy‐7, 8, 9, 10‐tetrahy‐drobenzo[a]pyrene, the ultimate carcinogenic metabolite of benzo[a]pyrene, resulted in inhibition of transcription as measured by radioactive precursor incorporation into RNA. The mechanism of