Effect of dietary antioxidants on benzo[a]pyrene metabolism in rat liver microsomes
β Scribed by Regine Kahl; Georg F. Kahl
- Publisher
- Elsevier Science
- Year
- 1983
- Tongue
- English
- Weight
- 113 KB
- Volume
- 28
- Category
- Article
- ISSN
- 0300-483X
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## Abstract A rat liver microsomeβmediated bacterial mutagenicity test showed 9βhydroxybenzo (__a__) pyrene to be significantly more effective as a preβmutagen than benzo (__a__) pyrene. Experiments measuring the ability of these compounds to be metabolically activated to moieties that alky late ex
## Abstract Individual metabolites of benzo (a)pyrene were isolated from rat liver microsomal incubation of the parent hydrocarbon, and subsequently bound to DNA in separate incubations with microsomes. Of the metabolites examined, by far the greatest binding resulted with 7,8βdihydroβ7,8βdihydroxy