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Inhibition by norharman of metabolism of benzo[a]pyrene by the microsomal mixed function oxidase of rat liver

✍ Scribed by Tadahiko Fujino; Akio Matsuyama; Minako Nagao; Takashi Sugimura

Book ID
118872215
Publisher
Elsevier Science
Year
1980
Tongue
English
Weight
565 KB
Volume
32
Category
Article
ISSN
0009-2797

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## Abstract A rat liver microsome‐mediated bacterial mutagenicity test showed 9‐hydroxybenzo (__a__) pyrene to be significantly more effective as a pre‐mutagen than benzo (__a__) pyrene. Experiments measuring the ability of these compounds to be metabolically activated to moieties that alky late ex