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Processive proteolysis by γ-secretase and the mechanism of Alzheimer’s disease

✍ Scribed by Wolfe, Michael S.

Book ID
118006987
Publisher
Walter de Gruyter GmbH & Co. KG
Year
2012
Tongue
English
Weight
169 KB
Volume
393
Category
Article
ISSN
1431-6730

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Objective: The most common pathogenesis for familial Alzheimer's disease (FAD) involves misprocessing (or alternative processing) of the amyloid precursor protein (APP) by c-secretase due to mutations of the presenilin 1 (PS1) gene. This misprocessing/alternative processing leads to an increase in t