At the frontline of Alzheimer’s disease treatment: γ-secretase inhibitor/modulator mechanism
✍ Scribed by Taisuke Tomita
- Publisher
- Springer-Verlag
- Year
- 2007
- Tongue
- English
- Weight
- 184 KB
- Volume
- 377
- Category
- Article
- ISSN
- 0028-1298
No coin nor oath required. For personal study only.
📜 SIMILAR VOLUMES
## Abstract Finding inhibitors of the first step of the amyloid cascade, Aβ~42~ generation, is a major goal of Alzheimer's disease drug development. Two target protease activities, β‐and γ‐secretase, were detected more than 10 years ago but progress in this area has been slow because the enzymes we
## Abstract β‐Amyloid cleaving enzyme‐1 (BACE1) has become a significant target for the therapy of Alzheimer's disease. After the discovery of the first non‐peptidomimetic β‐secretase inhibitors by Takeda Chemicals in 2001, several research teams focused on SAR development of these agents. The non‐