Inhibition and modulation of γ-secretase for Alzheimer’s disease
✍ Scribed by Michael S. Wolfe
- Publisher
- Springer-Verlag
- Year
- 2008
- Tongue
- English
- Weight
- 232 KB
- Volume
- 5
- Category
- Article
- ISSN
- 1933-7213
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Objective: The most common pathogenesis for familial Alzheimer's disease (FAD) involves misprocessing (or alternative processing) of the amyloid precursor protein (APP) by c-secretase due to mutations of the presenilin 1 (PS1) gene. This misprocessing/alternative processing leads to an increase in t
## Abstract Finding inhibitors of the first step of the amyloid cascade, Aβ~42~ generation, is a major goal of Alzheimer's disease drug development. Two target protease activities, β‐and γ‐secretase, were detected more than 10 years ago but progress in this area has been slow because the enzymes we