Process Development on (3 S ,4 S )-[( R )-1‘-(( tert -Butyldimethylsilyl)oxy)ethyl]-4-[( R )-1-carboxyethyl]-2-azetidinone: 1-β-Methylcarbapenem Key Intermediate
✍ Scribed by Lu, Xinbo; Xu, Zunle; Yang, Guojun; Fan, Rong
- Book ID
- 127330230
- Publisher
- American Chemical Society
- Year
- 2001
- Tongue
- English
- Weight
- 41 KB
- Volume
- 5
- Category
- Article
- ISSN
- 1083-6160
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📜 SIMILAR VOLUMES
A short stereoselective synthesis of the acetoxy azetidinone (1), an important precursor of several biologically active -lactam antibiotics, has been accomplished in seven steps and 32.8% overall yield from the easily available and inexpensive (R) ethyl 3-hydroxybutanoate.
Di-n-butyl-, triphenyl and tri-n-butyltin derivatives of 3S,4S-3-[(R)-1-(tert-butyldimethylsilyloxy)ethyl-4-[(R)-1-carboxyethyl]-2-azetidinone were synthesized and characterized. Their antitumour activity was screened against seven tumoural cell lines of human origin. Copyright