## Synthesis of 2-(Hydroxymethyl)-1β-methylcarbapenem. Chemoselective Organometallic Addition to 3-Substituted 4-[(R)-1-Carboxyethyl]azetidin-2-one. -A new method to introduce the α-hydroxymethyl function at the 2-position of the carbapenem system in an early stage of the synthesis is investigate
ChemInform Abstract: A Facile Synthesis of (4S)-4-((1R)-1-Carboxyethyl)-1-(tert- butyldimethylsilyl)azetidin-2-one: Key Intermediate of 1-β- Methylcarbapenems.
✍ Scribed by M. SEKI; T. MIYAKE; T. IZUKAWA; H. OHMIZU
- Publisher
- John Wiley and Sons
- Year
- 2010
- Weight
- 32 KB
- Volume
- 28
- Category
- Article
- ISSN
- 0931-7597
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Synthetic Studies on Sphingolipids. Part 4. Improved Synthesis of (4S)-4-[(1S,2R)-1,2-Epoxybut-3-enyl]-2-phenyl-2-oxazoline, a Key Intermediate for Sphingolipids. -A novel route to the title compound (VIII) is reported with an oxidative bromination [(VI) → (VII)] as the key step.