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Preventive effect of germanium dioxide on the inhibition of gap junctional intercellular communication by TPA

✍ Scribed by Kyung-Sun Kang; Jun-Won Yun; ByoungSu Yoon; Yoon-Kyu Lim; Yong-Soon Lee


Book ID
117466884
Publisher
Elsevier Science
Year
2001
Tongue
English
Weight
503 KB
Volume
166
Category
Article
ISSN
0304-3835

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## Abstract The phorbol ester, 12‐__O__‐tetradecanoylphorbol‐13‐acetate (TPA), is a potent inhibitor of gap junctional intercellular communication (GJIC). This inhibition requires activation of protein kinase C (PKC), but the events downstream of this kinase are not known. Since PKC can activate ex