Prevention of cisplatin-induced ototoxicity by the inhibition of gap junctional intercellular communication in auditory cells
β Scribed by Kim, Yeon Ju; Kim, Jangho; Tian, Chunjie; Lim, Hye Jin; Kim, Young Sun; Chung, Jong Hoon; Choung, Yun-Hoon
- Book ID
- 125338172
- Publisher
- Springer
- Year
- 2014
- Tongue
- English
- Weight
- 824 KB
- Volume
- 71
- Category
- Article
- ISSN
- 1420-682X
No coin nor oath required. For personal study only.
π SIMILAR VOLUMES
## Abstract The plasmaβmembrane association and transforming activity of the ras oncoprotein p21 are dependent upon posttranslational farnesylation. Farneslyl synthesis and p21 ras farnesylation are inhibited by hydroxmethylglutarylβCoA reductase inhibitors such as lovastatin. In this study, we exa
Many nongenotoxic hepatocarcinogens can induce cell proliferation, and inhibit apoptosis and gap-junctional-intercellular communication (GJIC). GJIC, the movement of small molecules (less than 1.2 kD) through membrane channels, is important in regulating cellular homeostasis and differentiation. The