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Prevalence of parkin gene mutations and variations in idiopathic Parkinson's disease

✍ Scribed by Rashmi Sinha; Brad Racette; Joel S. Perlmutter; Abbas Parsian


Book ID
116820078
Publisher
Elsevier Science
Year
2005
Tongue
English
Weight
115 KB
Volume
11
Category
Article
ISSN
1353-8020

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## Abstract Parkin, an E2‐dependent ubiquitin protein ligase, carries pathogenic mutations in patients with autosomal recessive juvenile parkinsonism, but its role in the late‐onset form of Parkinson's disease (PD) is not firmly established. Previously, we detected linkage of idiopathic PD to the r