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Prevalence of factor V Leiden mutation in various populations

✍ Scribed by F.H. Herrmann; M. Koesling; W. Schröder; R. Altman; R. Jiménez Bonilla; S. Lopaciuk; J.L. Perez-Requejo; J.R. Singh

Publisher
John Wiley and Sons
Year
1997
Tongue
English
Weight
31 KB
Volume
14
Category
Article
ISSN
0741-0395

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✦ Synopsis

Resistance to activated protein C (APC) is the most common inherited risk factor for venous thrombosis. Most cases of APC resistance are caused by the point mutation nt 1691 G-A in factor V gene, referred to as factor V Leiden mutation. As initially shown in a Dutch population, this mutation has a carrier rate of 2.9%, the most frequent genetic disposition for thrombophilia and deep venous thrombosis. By large-scale epidemiological studies we have determined the prevalence of factor V Leiden mutation in populations from Poland (200), Argentina (215), Venezuela (126), Costa Rica (196), and India (150). The prevalences have been estimated for Poland (Warsaw) 5.0%, Argentina (Buenos Aires) 5.1%, Venezuela (Valencia) 1.6%, Costa Rica (San José) 2.0%, and India (Punjab) 1.3%. Based on worldwide distribution, it can be hypothesized that the factor V Leiden mutation has originated and accumulated in central European Caucasians and spread over the world by migration. Genet. Epidemiol. 14:403-411, 1997.

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