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Preussomerins and Deoxypreussomerins: Novel Inhibitors of Ras Farnesyl-Protein Transferase

โœ Scribed by Singh, Sheo B.; Zink, Deborah L.; Liesch, Jerrold M.; Ball, Richard G.; Goetz, Michael A.; Bolessa, Evon A.; Giacobbe, Robert A.; Silverman, Keith C.; Bills, Gerald F.

Book ID
126107260
Publisher
American Chemical Society
Year
1994
Tongue
English
Weight
1009 KB
Volume
59
Category
Article
ISSN
0022-3263

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Novel Tricyclic Aminoacetyl and Sulfonamide Inhibitors of RAS Farnesyl Protein Transferase. -It is shown that derivatization of the amino group with a phthaloyl moiety increases inhibitory activity of the title compounds, cf. (IIIc) and (IIId). The potent inhibitors (III) and (V) are non-peptidic,