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Presenilin-1 polymorphism and Alzheimer's disease

โœ Scribed by Patrick Kehoe; Julie Williams; Simon Lovestone; Gordon Wilcock; MichaelJ. Owen; UK Alzheimer's Disease Collaborative Group; Constantin Bouras; Panteleimon Giannakopoulos; Junichi Schioi; Nikolaos Tezapsidis; NikolaosK. Robakis; Susumu Higuchi; Taro Muramatsu; Sachio Matsushita; Hiroyuki Arai; Hidetada Sasaki; WilliamK. Scott; JohnH. Growdon; AllenD. Roses; JonathanL. Haines; MargaretA. Pericak-Vance

Book ID
118561119
Publisher
The Lancet
Year
1996
Tongue
English
Weight
954 KB
Volume
347
Category
Article
ISSN
0140-6736

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## Wragg et al. [1996: Lancet 347:509-512] recorded an association between the intronbased presenilin 1 (PS1) genotype 1/1 and late-onset Alzheimer's disease (AD). This study was performed to determine if there is a similar association in the Chinese population. Ninety-one AD cases, 50 multiinfarc

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Mutations in the Presenilin 1 (PS1) gene on chromosome 14 cause most early-onset familial Alzheimer's disease (AD). An intronic polymorphism in the PS1 gene was recently identified and reported to be associated with late-onset AD [Wragg et al., Lancet 347: 509-512, 1996]. The authors found an excess