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Presenilin-1 polymorphism and Alzheimer's disease

✍ Scribed by Michael J Owen; Patrick Kehoe; Julie Williams

Book ID
118552115
Publisher
The Lancet
Year
1996
Tongue
English
Weight
17 KB
Volume
348
Category
Article
ISSN
0140-6736

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Mutations in the Presenilin 1 (PS1) gene on chromosome 14 cause most early-onset familial Alzheimer's disease (AD). An intronic polymorphism in the PS1 gene was recently identified and reported to be associated with late-onset AD [Wragg et al., Lancet 347: 509-512, 1996]. The authors found an excess