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Presence of oncornavirus-like particles in the P388 murine leukemic cell line

✍ Scribed by J. M. Schmidt; G. R. Pettit


Book ID
112656217
Publisher
Springer
Year
1978
Tongue
English
Weight
774 KB
Volume
34
Category
Article
ISSN
1420-682X

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## Abstract An oncornavirus‐like agent has been described in HeLa cells of human origin (Gelderblom __et al.__, 1974). The investigation of its protein constituents revealed a pattern similar to but different from that of known oncornaviruses. Six polypeptides with molecular weights (mw) between 12

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## Abstract Oncornavirus‐like particles observed and purified from HeLa cell culture supernates have a density in sucrose of 1.16‐1.17 g/cm^3^. They contain DNA polymerase and ribonuclease activities with properties characteristic of reverse transcriptase and ribonuclease H of known oncornaviruses.