Tritiated N-chloracetyl-DL-phenylalanine, obtained by reduction of the N-chloracetyl-dehydrophenylalanine with tritiated hydrogen, is hydrolysed by carboxypeptidase A . The method gives L-phenyl-al~nine-2,3-~H of high optical purity and with any specific activity up to 60 curies per millimole.
Preparation of tritium-labelled dextran and inulin
✍ Scribed by G. P. Akulov; Ju. L. Kaminski; N. A. Korsakova; B. K. Kudelin
- Publisher
- John Wiley and Sons
- Year
- 1992
- Tongue
- French
- Weight
- 143 KB
- Volume
- 31
- Category
- Article
- ISSN
- 0022-2135
No coin nor oath required. For personal study only.
✦ Synopsis
Abstract
Tritiated dextran and inulin were prepared by both a catalytic solid state and a liquid phase isotope exchange with gaseous tritium. The liquid phase procedure is convenient for preparation of the polysaccharides with specific activities up to 5 mCi/g, while the solid state procedure allows specific activities up to 700 mCi/g.
📜 SIMILAR VOLUMES
## Abstract A method for preparing tritium‐labelled ryanodine is described. The alkaloid was first brominated, and the bromoryanodines were separated from the reaction mixture by thin layer chromatography; NMR analysis at this stage showed substitution of pyrrole protons by bromine. Bromoryanodine
## Abstract The synthesis of d, l, ‐12‐bromocamptothecin (**2d**) from camptothecin (**1**) is described. Reduction of the bromo derivative **2d** with tritium gas in the presence of palladium on carbon afforded d, l‐camptothecin 12‐^3^H having a specific activity of 29 Ci/mmol. A simpler labelling
## Abstract The preparation of tritiated phosphoryl choline containing linear polymers by the reduction of an acetylenically unsaturated polymer with tritium gas is described. Homogeneous catalysis was used and the product was analysed by ^1^H and ^3^H‐nmr spectroscopy. The use of lanthanide shift
## Abstract α‐Dihydrograyanotoxin II has been labelled with tritium at the C‐10 and C‐19 positions by catalytic hydrogenation of grayanotoxin II. Pd‐catalyzed reduction in tetrahydrofuran produced the α‐form exclusively. The compound was obtained with specific activity 1.21 Ci/mmole and with 99% ra