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Preparation of sodium 2-mercapto-[14C]ethanesulfonate

✍ Scribed by J. Jarý; V. Grossmann; S. Doležal; J. Labsk´

Publisher
John Wiley and Sons
Year
1989
Tongue
French
Weight
190 KB
Volume
27
Category
Article
ISSN
0022-2135

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✦ Synopsis

Starting from C1-14Cl ethanol 1 , 2-dibrom-C14C1ethane was prepared by an usual method through C14C3ethylene. Sodium sulfite was alkylated by 1,2-dibrom--C Clethane and the formed sodium 2-br0m-L~~Clethane sulfonate was transferred without isolation to a labelled 2-I: (aminoiminomethyl) thiol -C14C1 ethanesulfonic acid. After purification by crystallization of the acid 2-mercapto-C14C1 ethanesulfonic acid was prepared through guanidinium salt. After the neutralization of 2-mercapto-[l4C1 ethanesulfonic acid by sodium hydroxide the corresponding sodium salt with specific activity 0.083 pCi/mmol ( 0 . 3 1 MBq/mmol) was prepared.

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