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Preparation of N-phenyl-(S)-prolinol-derived P,N-ligands and their application in Pd-catalyzed asymmetric allylic alkylation

✍ Scribed by Biao Jiang; Zuo-Gang Huang; Ke-Jun Cheng


Book ID
108284065
Publisher
Elsevier Science
Year
2006
Tongue
English
Weight
222 KB
Volume
17
Category
Article
ISSN
0957-4166

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✍ Xiangping Hu; Huilin Chen; Xinquan Hu; Huicong Dai; Changmin Bai; Junwei Wang; Z 📂 Article 📅 2002 🏛 Elsevier Science 🌐 French ⚖ 189 KB

A family of novel ferrocenylphosphine-amidine ligands derived from (R)-(S)-PPFNH 2 -R 5 was applied to the palladium-catalyzed asymmetric allylic alkylation of 1,3-diphenylprop-2-en-1-yl acetate 8a or pivalate 8b with dimethyl malonate. Up to 94% e.e. was achieved when ligand 6b was used.