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Synthesis of New Bicyclic P−N Ligands and Their Application in Asymmetric Pd-Catalyzed π-Allyl Alkylation and Heck Reaction

✍ Scribed by Gilbertson, Scott R.; Genov, Daniel G.; Rheingold, Arnold L.


Book ID
118045908
Publisher
American Chemical Society
Year
2000
Tongue
English
Weight
63 KB
Volume
2
Category
Article
ISSN
1523-7060

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A family of novel ferrocenylphosphine-amidine ligands derived from (R)-(S)-PPFNH 2 -R 5 was applied to the palladium-catalyzed asymmetric allylic alkylation of 1,3-diphenylprop-2-en-1-yl acetate 8a or pivalate 8b with dimethyl malonate. Up to 94% e.e. was achieved when ligand 6b was used.