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Preparation of an aromatic synthon for maytansinoid synthesis

✍ Scribed by Goodwin, Thomas E.; Orlicek, Shari G.; Adams, N. Renee; Covey-Morrison, Lynn A.; Jenkins, J. Steve; Templeton, Gary L.

Book ID
127079140
Publisher
American Chemical Society
Year
1985
Tongue
English
Weight
600 KB
Volume
50
Category
Article
ISSN
0022-3263

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## Abstract The dienal **14** and the ketone **19**, both potential building blocks of maytansinoids, were synthesized starting from ethyl vanillate (**2**) __via__ the aldehyde **9**. It could be shown in a preliminary experiment that the dienal **14** can be coupled with 2‐lithio‐1,3‐dithiane to