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Building Blocks for the Synthesis of Maytansinoids. Preliminary Communication

✍ Scribed by Erwin Götschi; Fernand Schneider; Hans Wagner; Karl Bernauer

Publisher
John Wiley and Sons
Year
1977
Tongue
German
Weight
197 KB
Volume
60
Category
Article
ISSN
0018-019X

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✦ Synopsis

Abstract

The dienal 14 and the ketone 19, both potential building blocks of maytansinoids, were synthesized starting from ethyl vanillate (2) via the aldehyde 9. It could be shown in a preliminary experiment that the dienal 14 can be coupled with 2‐lithio‐1,3‐dithiane to afford compound 16 which exhibits the correctly substituted aromatic part of maytansine as well as its C(9) to C(15) moiety.

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