✦ LIBER ✦

Synthesis of chiral building blocks for cephalostatin analogues

✍ Scribed by Uzma Yunus; Rashid Iqbal; Ekkhard Winterfeldt

Publisher: Journal of Heterocyclic Chemistry
Year: 2005
Tongue: English
Weight: 140 KB
Volume: 42
Category: Article
ISSN: 0022-152X
DOI: 10.1002/jhet.5570420607

No coin nor oath required. For personal study only.

✦ Synopsis

The present paper describes the synthesis of 5-azido-6-ketones ( 14) and 6-hydroxy-5-ketone (20) from Hajos Wiechert ketone as chiral building blocks for cephalostatin analogues . The synthesis of symmetric cephalostatin analogue from 6-hydroxy-5-ketone has also been reported. The characterization of the each synthesized compounds was carried out by IR, 1 H-NMR, 13 C-NMR and High resolution Mass Spectrometry.

📜 SIMILAR VOLUMES

Synthesis of Chiral Building Blocks for

Synthesis of Chiral Building Blocks for Cephalostatin Analogues.

✍ Uzma Yunus; Rashid Iqbal; Ekkhard Winterfeldt 📂 Article 📅 2006 🏛 John Wiley and Sons ⚖ 22 KB 👁 1 views

## Abstract For Abstract see ChemInform Abstract in Full Text.

ChemInform Abstract: Chiral Building Blo

ChemInform Abstract: Chiral Building Blocks for Drug Synthesis

✍ D. STRACK 📂 Article 📅 2010 🏛 John Wiley and Sons ⚖ 23 KB

Preparation of Chiral Building Blocks fo

Preparation of Chiral Building Blocks for Starburst Dendrimer Synthesis

✍ Jean-Marc Lapierre; Konstantinos Skobridis; Dieter Seebach 📂 Article 📅 1993 🏛 John Wiley and Sons 🌐 German ⚖ 977 KB

For recent reviews and highlights on dendrimers, see [I]. ' ) The compound that would result from the reduction of 10 can, however, be prepared by a simpler procedure, see Scheme 2.

Synthesis of substituted chiral piperazi

Synthesis of substituted chiral piperazinones as building blocks for peptidomimetics

✍ Kolter, Thomas ;Dahl, Christina ;Giannis, Athanassios 📂 Article 📅 1995 🏛 John Wiley and Sons 🌐 English ⚖ 533 KB

A new approach to 3,6-disubstituted chiral piperazinones 6a, b and ?a, b from D-glucosamine hydrochloride (1) or N-Z-Dglucosamine (8) and L-amino acid derivatives 2a, b or 9a, b is presented. Both final products and the intermediate pseudopeptides constitute valuable starting materials for the synth

Enantiomerically pure chiral building bl

Enantiomerically pure chiral building blocks for syntheses of carbocyclic nucleoside analogues: A formal synthesis of aristeromycin

✍ Helmchen, Günter ;Krotz, Achim ;Neumann, Hans-Peter ;Ziegler, Manfred L. 📂 Article 📅 1993 🏛 John Wiley and Sons 🌐 English ⚖ 521 KB

## Abstract (+)‐(1__R__,4__R__)‐Bicyclo[2.2.1]hept‐5‐en‐2‐one (7) was prepared in 78.5% yield by oxidative degradation of (+)‐(1__R__)‐__endo__‐bicyclo[2.2.1]hept‐5‐ene‐2‐carboxylic acid (4) by using an improved procedure for the oxidation of the dianion of 4 with dioxygen. Dihydroxylation of 7 wit

Synthesis of New Chiral Building Blocks

Synthesis of New Chiral Building Blocks for Novel Peptide Nucleic Acids

✍ Wu Jie; Xu Xiao-Yu; Liu Ke-Liang 📂 Article 📅 2010 🏛 John Wiley and Sons 🌐 English ⚖ 678 KB

## Abstract __N__‐Boc protected amino acids of analogues of peptide nucleic add (PNA.), which are a class of conformationally constrained building blocks based on 4‐aminoproline backbone with chirality at 2‐C and 4‐C, have been synthesized. Those monomers can be used for the construction of novel p