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Improved Synthesis of Anhydrohexitol Building Blocks for Oligonucleotide Synthesis

✍ Scribed by De Bouvere, Bart ;Kerremans, Luc ;Rozenski, Jef ;Janssen, Gerard ;van Aerschot, Arthur ;Claes, Paul ;Busson, Roger ;Herdewijn, Piet

Publisher: John Wiley and Sons
Year: 1997
Tongue: English
Weight: 930 KB
Volume: 1997
Category: Article
ISSN: 0947-3440
DOI: 10.1002/jlac.199719970724

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✦ Synopsis

Abstract

The synthesis of the four building blocks used for the preparation of hexitol nucleic acids were optimized. The nucleoside analogues with a purine base moiety are best prepared by a nucleophilic substitution reaction, whereas the pyrimidine nucleosides can best be obtained using Mitsunobu‐type conditions.

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