Synthesis of a chiral synthon for the la
β
Bruce D. Roth; W.Howard Roark
π
Article
π
1988
π
Elsevier Science
π
French
β 229 KB
The stereoselective Michael addition of alcohols dihydro-2tj-pyran-2-one afforded high yields of a key chiral portion of compactin and mevinolin. to 6-tosyloxymethyl-5,6synthon for the lactone Compactin (1) mevinolin (2) and related compounds have been cholesterol levels in animal models and man and