Preparation of a new o-nitrobenzyl resin for solid-phase synthesis of tert-butyloxycarbonyl-protected peptide acids
β Scribed by Rich, Daniel H.; Gurwara, S. K.
- Book ID
- 121411314
- Publisher
- American Chemical Society
- Year
- 1975
- Tongue
- English
- Weight
- 622 KB
- Volume
- 97
- Category
- Article
- ISSN
- 0002-7863
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## Abstract An improved method for the preparation of Merrifield resin esters is presented. This method is rapid, is free of racemization, and is not complicated by a quaternization side reaction. Chloromethylated resin beads, __t__βbutoxycarbonyl amino acid, and potassium __t__βbutoxide are heated
N-[9-(hydroxymethyl) .2.tluorenyl] succinamic acid may be used as an anchoring linkage for the preparation of protected peptide segments in combination with Boc/Bzl' protection scheme. The new handle proved to be stable to the usual conditions of solid-phase peptide synthesis and gave the protected