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A new flourene-derived anchor for solid-phase synthesis of protected peptides

✍ Scribed by Francesc Rabanal; Ernest Giralt; Fernando Albericio

Publisher
Elsevier Science
Year
1992
Tongue
French
Weight
298 KB
Volume
33
Category
Article
ISSN
0040-4039

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✦ Synopsis

N-[9-(hydroxymethyl)

.2.tluorenyl] succinamic acid may be used as an anchoring linkage for the preparation of protected peptide segments in combination with Boc/Bzl' protection scheme. The new handle proved to be stable to the usual conditions of solid-phase peptide synthesis and gave the protected peptide in high yields and purities by neatment with piperidine or morpholine.

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