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Reagents for Combinatorial Organic Synthesis: Development of a New o-Nitrobenzyl Photolabile Linker for Solid Phase Synthesis

✍ Scribed by Holmes, Christopher P.; Jones, David G.

Book ID
118183011
Publisher
American Chemical Society
Year
1995
Tongue
English
Weight
409 KB
Volume
60
Category
Article
ISSN
0022-3263

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πŸ“œ SIMILAR VOLUMES

A photolabile β€˜traceless’ linker for sol
A photolabile β€˜traceless’ linker for solid-phase organic synthesis
✍ James R Horton; Louise M Stamp; Anne Routledge πŸ“‚ Article πŸ“… 2000 πŸ› Elsevier Science 🌐 French βš– 75 KB

A photolabile linker based on a thiohydroxamic acid has been shown to be an efficient 'traceless' linker, revealing an aliphatic CH bond on photolysis at 350 nm. Methods for the synthesis, loading and photolytic cleavage of the linker are described.