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Preparation of 6-3H glucocerebroside

✍ Scribed by Marvin C. McMaster; Norman S. Radin

Publisher
John Wiley and Sons
Year
1977
Tongue
French
Weight
193 KB
Volume
13
Category
Article
ISSN
0022-2135

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✦ Synopsis

Abstract

Glucocerebroside (1–0‐β‐glucosyl ceramide) can be labeled with ^3^H‐borohydride at the 6‐position of the glucose moiety. The 6‐trityl ether of cerebroside is formed first, the remaining hydroxyl groups are acetylated, the trityl group is removed, and the free 6‐hydroxyl group is oxidized to an aldehyde. The carbonyl group is then reduced with borohydride and the acetyl groups are removed, regenerating the original glycolipid.

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