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Preparation of 3,3′-dichlorobenzidine-(phenyl-U-14C) dihydrochloride

✍ Scribed by W. P. Duncan; J. C. Wiley Jr.; W. C. Perry

Publisher: John Wiley and Sons
Year: 1977
Tongue: French
Weight: 208 KB
Volume: 13
Category: Article
ISSN: 0022-2135
DOI: 10.1002/jlcr.2580130302

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✦ Synopsis

Abstract

A novel five‐step synthesis of 3,3′‐ dichlorobenzidine‐(phenyl‐U^14^C) dihydrochloride is described. The method consists of the preparation of benzidine‐(phenyl‐U‐^14^C) followed by acetylation, chlorination with N‐chlorosuccinimide (NCS), and hydrolysis. The specific activity of the product was 31.2 mCi/mmole and the overall radiochemical yield was 20% [based on nitrobenzene‐(phenyl‐U‐^14^C)].

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