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The preparation of Nτ- [3H]methylhistamlne dihydrochloride and Nτ-methyl[α,β,2,4,5-14c5]histamlne dihydrochloride

✍ Scribed by R. I. Knight; D. J. Morecombe; D. Saunders; I. R. Smith

Publisher
John Wiley and Sons
Year
1979
Tongue
French
Weight
280 KB
Volume
16
Category
Article
ISSN
0022-2135

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✦ Synopsis

I n o r d e r t o s t u d y some a s p e c t s of t h e c e n t r a l metabolism of h i s t a m i n e r 3 3 w e have prepared N -[ H]methylhistamine d i h y d r o c h l o r i d e from [ Hlmethyl i o d i d e by chemical s y n t h e s i s and NT-methyl [a,8,2,4,5-14C51histamine d i h y d r o c h l o r i d e from [ ~, 8 , 2 , 4 , 5 -' ~c ]histamine d i h y d r o c h l o r i d e by an enzymatic method. Key words: N -[ H]methylhistamine d i h y d r o c h l o r i d e , NT-methyl [ a , @ , 2 , 4 , 5 -C5]h i s t a m i n e d i h y d r o c h l o r i d e , chemical s y n t h e s i s , enzymatic s y n t h e s i s . 5 T 3 14 0362-4803/79/0516-0761~01~00 01979 by John Wiley h Sons, Ltd.

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