Buspirone 1 is a novel, clinically effective anxiolytic agent which is devoid of the sedative, anticonvulsant or muscle relaxant properties normally associated with the benzodiazepines. Buspirone labelled with both radioactive (14C) and stable (15N) isotopes was required in order to investigate the
Preparation of 14C-Labelled Vincristine and N-Desmethyl-N-formyl-leurosine
✍ Scribed by Gábor Zóyomi; Karola Jovánovics; Lajos Dancsi
- Publisher
- John Wiley and Sons
- Year
- 1977
- Tongue
- French
- Weight
- 180 KB
- Volume
- 13
- Category
- Article
- ISSN
- 0022-2135
No coin nor oath required. For personal study only.
✦ Synopsis
Abstract
^14^C‐Labelled vincristine was prepared from N‐desmethyl vinblastine by formylation with ^14^C‐formic acid. Excess radioactive formic acid was recovered as sodium formate. ^14^C‐Labelled N‐desmethyl‐N‐formyl‐leurosine was prepared analogously.
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Propylproline and N-demethyl-lincomycin, two i n t e r m e d i a t e s i n l i n c o m y c i n b i o s y n t h e s i s , were prepared i n r a d i o l a b e l e d form. [\*\*C]-labeled N-demethyllincomycin was s y n t h e s i z e d by a r e s t i n g cell suspension of a lincomycin n e g a t i v e
## Abstract A synthetic procedure for C‐14‐labeled N‐methyl‐N‐nitrosoaniline is presented. Separate labeling of the methyl and phenyl side chains was achieved by using C‐14‐labeled methyl iodide and aniline, respectively. The overall yield of the four reactions was 62% and the final products were s
## Abstract O,O‐Vi‐ [1‐^14^C]‐ethyl S‐ [N‐ethoxycarbonyl‐N‐methylcarbamoylmethyl] phosphorothiolothionate has been prepared with a specific activity of 1.97 mCi mmol^−1^. The procedure involved the interaction of [1‐^14^C]‐ethanol with phosphorus pentasulphide in benzene, followed by conversion of
## Abstract Carbonation of the aryl lithium obtained from p‐N,N(dimethylamino)bromobenzene with carbon‐14 labeled carbon dioxide, followed by esterification gave [CO~2~‐^14^C]p‐N,N(dimethylamino)benzoate 2‐ethylhexyl ester (Padimate‐O). This material underwent slow decomposition to [^14^C]N‐nor‐Pad