Preparation of carbon-14 labelled mecarbam (O,O-DI-[1-14c]-ethyl s-[N-ethoxycarbonyl-N-methylcarbamoylmethyl] phosphorothiolothionate)

✍ Scribed by H. R. Hudson; M. Pianka; L. Powroznik; V. P. Lynch

• Publisher: John Wiley and Sons
• Year: 1980
• Tongue: French
• Weight: 144 KB
• Volume: 17
• Category: Article
• ISSN: 0022-2135
• DOI: 10.1002/jlcr.2580170304

✦ Synopsis

Abstract

O,O‐Vi‐ [1‐^14^C]‐ethyl S‐ [N‐ethoxycarbonyl‐N‐methylcarbamoylmethyl] phosphorothiolothionate has been prepared with a specific activity of 1.97 mCi mmol^−1^. The procedure involved the interaction of [1‐^14^C]‐ethanol with phosphorus pentasulphide in benzene, followed by conversion of the so‐formed diethyl dithiophosphoric acid to its potassium salt and reaction of this with ethyl N‐chloroacetyl‐N‐methylcarbamate in acetone. G.l.c. analysis of the final product in benzene solution showed the purity to be not less than 97 %.