Preparation and pharmacokinetics of 11C labeled stavudine (d4T)
โ Scribed by Eli Livni; Mark Berker; Shawn Hillier; Stephen C Waller; Marc D Ogan; Robert P Discordia; J.Kent Rienhart; Robert H Rubin; Alan J Fischman
- Book ID
- 116798740
- Publisher
- Elsevier Science
- Year
- 2004
- Tongue
- English
- Weight
- 207 KB
- Volume
- 31
- Category
- Article
- ISSN
- 0969-8051
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๐ SIMILAR VOLUMES
1-(1'-[14C1-2',3'-Dideoxy-~-~glyceropent-2'-enofuranosy~~thymine (1'-114C1-d4T), was synthesized kom l-[14Cl-ribose, 1, in 7 steps in an overall yield of 29.3%. 1-[14C]-Ribose was converted in one step to l-O-methy1-2,3,5-tri-O-benzoylribofuranoside 2 in quantitative yield. Compound 2 was converted
## Abstract A rapid and mild procedure for the preparation of [Nโ7โmethylโ^11^C] caffeine is described. Gaseous ^11^Cโmethyl iodide wa led into dimethyl sulphoxide (DMSO), containing theophylline (1,3โdimethylaxanthine) and sodium hydride. Purification of the reaction product was achieved by High P