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Synthesis of (.+-.)-4′-Ethynyl and 4′-Cyano Carbocyclic Analogues of Stavudine (d4T).

✍ Scribed by Hiroki Kumamoto; Kazuhiro Haraguchi; Hiromichi Tanaka; Takao Nitanda; Masanori Baba; Ginger E. Dutschman; Yung-Chi Cheng; Keisuke Kato


Book ID
101988956
Publisher
John Wiley and Sons
Year
2006
Weight
20 KB
Volume
37
Category
Article
ISSN
0931-7597

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Synthesis of 1′-[14C]-stavudine® (d4T)
✍ Robert P. Discordia 📂 Article 📅 1996 🏛 John Wiley and Sons 🌐 French ⚖ 485 KB 👁 2 views

1-(1'-[14C1-2',3'-Dideoxy-~-~glyceropent-2'-enofuranosy~~thymine (1'-114C1-d4T), was synthesized kom l-[14Cl-ribose, 1, in 7 steps in an overall yield of 29.3%. 1-[14C]-Ribose was converted in one step to l-O-methy1-2,3,5-tri-O-benzoylribofuranoside 2 in quantitative yield. Compound 2 was converted