𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Synthesis of (±)-4′-Ethynyl and 4′-Cyano Carbocyclic Analogues of Stavudine (d4T)

✍ Scribed by Kumamoto, Hiroki; Haraguchi, Kazuhiro; Tanaka, Hiromichi; Kato, Keisuke; Nitanda, Takao; Baba, Masanori; Dutschman, Ginger E.; Cheng, Yung-Chi


Book ID
118746799
Publisher
Taylor and Francis Group
Year
2005
Tongue
English
Weight
254 KB
Volume
24
Category
Article
ISSN
0732-8311

No coin nor oath required. For personal study only.


📜 SIMILAR VOLUMES


Synthesis of 1′-[14C]-stavudine® (d4T)
✍ Robert P. Discordia 📂 Article 📅 1996 🏛 John Wiley and Sons 🌐 French ⚖ 485 KB 👁 2 views

1-(1'-[14C1-2',3'-Dideoxy-~-~glyceropent-2'-enofuranosy~~thymine (1'-114C1-d4T), was synthesized kom l-[14Cl-ribose, 1, in 7 steps in an overall yield of 29.3%. 1-[14C]-Ribose was converted in one step to l-O-methy1-2,3,5-tri-O-benzoylribofuranoside 2 in quantitative yield. Compound 2 was converted