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The preparation of 11C-labeled caffeine

✍ Scribed by H. R. Denutte; T. Vandewalle; H. J. Cattoir; C. Vandecasteele; J. A. Jonckheere; G. Slegers; C. F. Gelijkens; A. P. De Leenheer

Publisher
John Wiley and Sons
Year
1982
Tongue
French
Weight
229 KB
Volume
19
Category
Article
ISSN
0022-2135

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✦ Synopsis

Abstract

A rapid and mild procedure for the preparation of [N‐7‐methyl‐^11^C] caffeine is described. Gaseous ^11^C‐methyl iodide wa led into dimethyl sulphoxide (DMSO), containing theophylline (1,3‐dimethylaxanthine) and sodium hydride. Purification of the reaction product was achieved by High Performance Liquid Chromatogrphy (HPLC).

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