Easy preparative scale syntheses of labelled xanthines: caffeine, theophylline and theobromine

✍ Scribed by Frédéric Balssa; Yves Bonnaire

• Publisher: John Wiley and Sons
• Year: 2007
• Tongue: French
• Weight: 151 KB
• Volume: 50
• Category: Article
• ISSN: 0022-2135
• DOI: 10.1002/jlcr.1154

✦ Synopsis

Abstract

Several easy preparative scale (0.5–1.5 g) syntheses of deuterium labelled caffeine, theophylline and theobromine are described. Some new selective syntheses of theophylline and theobromine have been developed. Labelled xanthines are of great interest in qualitative or quantitative isotope dilution‐mass spectrometry, coupled with gas or liquid chromatography, currently performed in anti‐doping and forensic laboratories. Copyright © 2007 John Wiley & Sons, Ltd.