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The preparation of 14C-labeled FK-506

✍ Scribed by Stephen P. O'connor; Robert L. Ellsworth; Mary Nallin Omstead; Rosalind G. Jenkins; Louis Kaplan

Publisher: John Wiley and Sons
Year: 1992
Tongue: French
Weight: 323 KB
Volume: 31
Category: Article
ISSN: 0022-2135
DOI: 10.1002/jlcr.2580310205

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✦ Synopsis

Abstract

Utilizing sodium [1−^14^C]propionate as a precursor, [^14^C]FK‐506, labeled at carbon atoms 10, 16, 18, 21a, 24, and 26, was produced by fermentative biosynthesis. Extractive isolation followed by chromatographic purification provided material of purity suitable for metabolism studies.

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