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Premature arthritis is a distinct type II collagen phenotype

✍ Scribed by Peter Kannu; John F. Bateman; Susan Randle; Shannon Cowie; Desiree du Sart; Shaun McGrath; Matthew Edwards; Ravi Savarirayan

Publisher
John Wiley and Sons
Year
2010
Tongue
English
Weight
353 KB
Volume
62
Category
Article
ISSN
0004-3591

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πŸ“œ SIMILAR VOLUMES

Juvenile arthritis and autoimmunity to t
Juvenile arthritis and autoimmunity to type II collagen
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Objective. Joint inflammation in juvenile rheumatoid arthritis (JRA) is sometimes associated with an autoimmune response to type II collagen (CII), a cartilage-specific protein. To test the hypothesis that down-regulation of autoimmunity to CII can be accomplished in JRA by oral administration of CI

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## Abstract ## Objective Previous studies have shown that an analog peptide of the immunodominant T cell determinant of type II collagen (CII), i.e., CII^256–276^(N^263^, D^266^), was able to suppress the immune response to CII and the development of arthritis in DR1‐transgenic mice. The present s