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Juvenile arthritis and autoimmunity to type II collagen

✍ Scribed by L. K. Myers; G. C. Higgins; T. H. Finkel; A. M. Reed; J. W. Thompson; R. C. Walton; J. Hendrickson; N. C. Kerr; R. K. Pandya-Lipman; B. V. Shlopov; P. Stastny; A. E. Postlethwaite; A. H. Kang

Publisher
John Wiley and Sons
Year
2001
Tongue
English
Weight
79 KB
Volume
44
Category
Article
ISSN
0004-3591

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✦ Synopsis

Objective. Joint inflammation in juvenile rheumatoid arthritis (JRA) is sometimes associated with an autoimmune response to type II collagen (CII), a cartilage-specific protein. To test the hypothesis that down-regulation of autoimmunity to CII can be accomplished in JRA by oral administration of CII, an openlabel study of CII was performed in 9 patients with JRA.

Methods. Seven rheumatoid factor-negative JRA patients with polyarticular disease and 2 JRA patients with pauciarticular disease (1 with early onset and 1 with late onset) were treated for 3 months with oral bovine CII. Patients were examined for disease activity and underwent routine laboratory testing at monthly intervals. Two of the patients had flares of disease when treatment was discontinued, and these patients were re-treated for an additional 3 months. To test the hypothesis that oral tolerance induces an immune deviation of T cells, peripheral blood mononuclear cells from patients were collected before and after treatment and cultured with CII. Supernatants and RNA were collected and analyzed for the presence of various cytokines.

Results. Eight patient trials met the criteria for

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