## Abstract Bronchial epithelial cells are often exposed to airborne mutagens that have the potential to induce genetic changes involved in the development of lung cancer. Although lung tumors often display alterations in the expression of oncogenes and/or tumor suppressor genes, the role of specif
Preferential modification of GC boxes by benzo[a]pyrene-7,8-diol-9,10-epoxide
โ Scribed by Arend Kootstra; Linda Kao Lew; Rodney S. Nairn; Michael C. Macleod
- Publisher
- John Wiley and Sons
- Year
- 1989
- Tongue
- English
- Weight
- 688 KB
- Volume
- 1
- Category
- Article
- ISSN
- 0899-1987
No coin nor oath required. For personal study only.
๐ SIMILAR VOLUMES
## Abstract Glutathione (GSH) conjugation of (+)โantiโbenzo[__a__]pyreneโ7,8โdiolโ9,10โepoxide [(+)โantiโBPDE], the activated metabolite of benzo[__a__]pyrene, is believed to be an important mechanism in detoxification of this environmental and dietary carcinogen. Here, we demonstrate that the intr
A chemical synthesis of the phenolic ester of the trio1 epoxide derivatives of carcinogenic benzo[alpyrene is described. The chemical synthesis of the various reactive metabolites has been an essential factor in elucidating the molecular mechanism that is responsible for QOlycyClic aromatic hydroca
Chlorophyllin (CHL), a water soluble derivative of the green pigment chlorophyll, was evaluated for its antimutagenic activity towards benzo[a]pyrene-7,8-dihydrodiol-9,10-epoxide (BPDE). CHL suppressed dose-dependently the formation of 8-azaguanine-resistant mutant colonies in Salmonella typhimurium
## Abstract The frequency of cell transformation was determined after treatment of normal hamster embryo cells with benzo(a)pyrene (BP) and six of its metabolites. These metabolites included the __trans__ 4,5โ, 7,8โ and 9,10โdihydrodiols; the 4,5โepoxide; and two stereoisomers of the nonโKโregion d