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Inhibition by chlorophyllin of forward and reverse bacterial mutagenicity of benzo[a]pyrene-7,8-dihydrodiol-9,10-epoxide

✍ Scribed by Young-Joon Surh

Publisher: John Wiley and Sons
Year: 1998
Tongue: English
Weight: 57 KB
Volume: 12
Category: Article
ISSN: 0951-418X
DOI: 10.1002/(sici)1099-1573(199812)12:8<580::aid-ptr364>3.0.co;2-f

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✦ Synopsis

Chlorophyllin (CHL), a water soluble derivative of the green pigment chlorophyll, was evaluated for its antimutagenic activity towards benzo[a]pyrene-7,8-dihydrodiol-9,10-epoxide (BPDE). CHL suppressed dose-dependently the formation of 8-azaguanine-resistant mutant colonies in Salmonella typhimurium TM677 treated with BPDE. Under the same experimental conditions, the cytotoxicity of this direct-acting mutagen was concomitantly blunted by CHL. The protective effect of CHL against BPDE mutagenicity was confirmed in the Salmonella histidine reversion assay CHL also reduced the in vitro covalent binding of BPDE to DNA.

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