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Preclinical toxicity and pharmacology of liposome-entrappedcis-bis-neodecanoato-trans-R,R-1,2-diaminocyclohexane platinum(II)

✍ Scribed by R. Perez-Soler; J. Lautersztain; L. C. Stephens; K. Wright; A. R. Khokhar


Publisher
Springer
Year
1989
Tongue
English
Weight
840 KB
Volume
24
Category
Article
ISSN
0344-5704

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✍ A. R. Khokhar; K. Wright; Z. H. Siddik; R. Perez-Soler πŸ“‚ Article πŸ“… 1988 πŸ› Springer 🌐 English βš– 495 KB

Blood and tissue levels of elemental platinum (Pt) were measured after the administration of a liposomally entrapped cisplatin analogue, cis-bis-neodecanoato-trans-R,R-1,2-diaminocyclohexane platinum (II) (L-NDDP). In mice bearing subcutaneous B16 melanoma tumors, Pt tumor levels were not significan