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Pharmacokinetics and tissue distribution of liposome-encapsulatedcis-bis-N-decyliminodiacetato-1,2-diaminocyclohexane-platinum (II)

✍ Scribed by J. Lautersztain; R. Perez-Soler; A. R. Khokhar; R. A. Newman; G. Lopez-Berestein

Publisher: Springer
Year: 1986
Tongue: English
Weight: 540 KB
Volume: 18
Category: Article
ISSN: 0344-5704
DOI: 10.1007/bf00262274

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Blood and tissue levels of elemental platinum (Pt) were measured after the administration of a liposomally entrapped cisplatin analogue, cis-bis-neodecanoato-trans-R,R-1,2-diaminocyclohexane platinum (II) (L-NDDP). In mice bearing subcutaneous B16 melanoma tumors, Pt tumor levels were not significan